How does PPARs help treat breast cancer?

How does PPARs help treat breast cancer?

Cancer is a disease in which cells in the body grow out of control. Except for skin cancer, breast cancer is the most common cancer in women worldwide. PPAR is highly beneficial for cancer-stricken patients and has been allegedly known to be effective to improve conditions of cancer. Hence, in this post we will be looking into benefits of PPAR and its effects towards cancer cells, especially breast cancer.


Overview of this post:

1. How does Breast Cancer come about?

2. What is PPAR?

3. How does PPAR treat Breast Cancer?

4. How to Buy PPAR Supplements?


Breast Cancer


Breast cancer is a disease in which cells in the breast grow out of control.



Breast cancer cells usually form a tumour that can often be seen on an x-ray or felt as a lump. Breast cancer occurs almost entirely in women, but men can get breast cancer, too. About 245,000 cases of breast cancer are diagnosed in women and about 2,200 in men.

There is strong evidence that consumption of alcoholic drinks, greater birthweight and adult attained height are causes of premenopausal breast cancer. There are different kinds of breast cancer.


Breast cancers can start from different parts of the breast. Most breast cancers begin in the ducts that carry milk to the nipple (ductal cancers). Some starts in the glands that make breast milk (lobular cancers). There are also other types of breast cancer that are less common like phyllodes tumour and angiosarcoma.


Breast cancer is one of the top cancer in women worldwide and is increasing particularly in developing countries where the majority of cases are diagnosed in late stages. Deaths from breast cancer have declined overtime but remain the second leading cause of cancer death among women overall and the leading cause of cancer death among women. The chance that a woman will die from breast cancer is about 1 in 38 (about 2.6%).

Breast cancer can spread when the cancer cells get into the blood or lymph system and are carried to other parts of the body. Breast cancer is treated in several ways included surgery, chemotherapy, hormonal therapy, biological therapy and radiation therapy. It depends on the kind of breast cancer and how far it has spread.



What is PPARs?


The Peroxisome Proliferator Activated Receptors (PPARs) is an emerging “star” in the biomedical industry which has been known as the one most promising biomedical molecule. In the molecular biology field, the PPARs are a group of nuclear receptor proteins which work as the transcription factors to regulate the expression of genes.


The PPARs act on DNA response elements with the nuclear retinoic acid receptor. PPARs are involved in various independent and DNA-dependent molecular and enzymatic pathways in adipose tissue, liver, and skeletal muscles.


PPARs mainly exist in three subtypes or isoforms: the PPAR alpha, the PPAR gamma, and the PPAR delta/beta.


The PPAR Alpha is widely expressed in body tissues. PPAR alpha is present in the skeletal muscle, the liver and the heart which plays the crucial role to lower the triglyceride level and energy homeostasis.


The PPAR beta/delta is active in many tissues and plays an important role to regulate the oxidation of fatty acids, ketone body synthesis and glucose sparing. The PPAR beta/ delta is present in many tissues but markedly in brain, lungs, skeletal muscle and skin. Besides, PPAR beta/ delta is effective in inhibiting inflammatory mediators.


The PPAR gamma is ubiquitous. It is present in almost all tissues including heart, muscle, colon, kidney, pancreas and spleen. The PPAR gamma is important in the regulation of lipid and glucose metabolism. This is crucial in allowing our body to adapt to the prevailing nutritional environment. On top of that, PPAR gamma is rich with anti-atherogenic and anti-inflammatory properties.


Benefits of PPARs


Clinical tests and medical evidence has shown that PPARs is highly beneficial for the body from numerous perspectives, which includes the following:


i. Enhances Blood Sugar Regulation for Diabetic Patients


PPARs increases Fibroblast Growth Factor 21(FGF-21) which is a hormone that regulates important metabolic pathways. It is beneficial to enhance insulin sensitivity and glucose in the blood. PPAR then acts as a key to facilitate the sensitivity of insulin and insulin secretion, thereby reducing the glucose in the blood. This will be able to help reduce the chance of getting diabetes and act as a controller for diabetic patients.


ii. Anti-Inflammation


PPARs also plays the roles of anti-inflammation and blocking inflammation. PPARs helps to reduce pain and inflammation and further prevent the production of various pro-inflammatory and angiogenic enzymes. Besides, PPAR has also been recognized in contributing significantly in the immune response through its ability to avoid the expression of inflammatory cytokines and directing various immune cells toward anti-inflammatory phenotypes.


iii. Reduce obesity and heart diseases


Activation of PPARs increases metabolism and body function which is crucial to treat diabetes mellitus, obesity, hypercholesterolemia and hypertension. PPARs will activate fatty acid catabolism and take part in controlling the assembly of lipoprotein. The excretion of PPARs which causes the browning of white fat which will be able to facilitate in the fight against obesity. Therefore, PPARs is beneficial in lowering blood triglyceride, hence lowering the density of Lipoprotein Cholesterol. PPARs have also been proven useful in reducing blood pressure and decreasing heart disease.


iv. Anti-Cancer Effect


PPARs Treatment & Prevention Of Diseases

- According to studies, when used correctly, PPARs will be very favourable to cancer therapy.

PPARs stimulation appears to inhibit proliferation of human colon cancer cell lines and to reduce poly formation. PPARs increases the antineoplastic effects of malignant cells. In other words, PPAR inhibits growing of proliferation and cancer cells (the bad proliferation).


v. Immunity


Activation of PPARs will enhance immunity cell proliferator capability which in other words, PPAR will boost our immunity.


vi. Anti-aging


Free radicals are causal agents in the process of aging. PPARs supports the healing process of damaged body tissues and are beneficial in the rejuvenation of cells. Besides, the antiapoptotic characteristic of PPARs has made it an effective “agent” in anti-aging.


How does PPARs treat Breast Cancer?


PPARs plays a major regulatory role in energy homeostasis and metabolic function. This means that PPARs will direct the exact amount of nutrients needed by your body to the exact tissues or organs, unifying the biological system, functions and processes.


This is highly beneficial as it will deter the mutated cancer cells from stealing and absorbing nutrients from the healthy tissues, resulting to the positive effect of starving the cancer cells. In other words, PPARs is effective in deterring the growth of cancer cells.


PPAR gamma is rich with anti-atherogenic and anti-inflammatory properties.


PPAR gamma is involved in the regulation of inflammation and immunity. PPARs modulates the body’s ability to regulate and decrease inflammation. Inflammation is a crucial factor here as it creates an environment that promotes both Angiogenesis and Metastasis, which is the spread of cancer. In this case, PPARs helps to stop the spreading of cancer cells.


Activation of PPARs will enhance immunity cell proliferator capability which in other words, PPARs will boost our immune system. On top of that, PPARs also plays the critical roles where it activates the cells functions and increase cells respondence by fuelling the cells to function properly.


PPARs also increase Dendritic Cell Activity which identifies mutated cells that are in error, such as cancer cells and commands the immune system, the Natural Killer T Cells to quickly and clearly attack the cancer cells and defeat them.


By fuelling the cells and boosting the immune system, PPARs help the cells to target and fight the cancer cells and hence it is effective to shrink the tumours.


Chemotherapy and radiotherapy are part of the treatment of cancer. The side effects of these therapies are highly damaging where there is a possibility that it may damage the liver, kidney, heart and even the bone marrow. If you have to go through chemotherapy for cancer, PPARs can help in the recovery process. It does so by supporting the healing process of damaged body tissues and are beneficial in the rejuvenation of cells. PPARs is helpful also in reducing the hypertension, endothelial dysfunction and organ damages caused by chemo or radio therapies. In this case, PPARs is critical to alleviate and even reverse the complications symptoms of cancer therapy by protecting the body tissues and organs from cancer therapy/treatment damages.


PPARs works in synergy with chemotherapy, radiation therapy and even surgery. Refer below to the testimony from Marilyn on how Simply Nature PPARs was able to help her become free from her breast cancer.


Simply Nature PPARs Marilyn on Breast Cancer


How to Buy PPAR Supplements?


There are several simple and effective ways to increase and activate PPARs in our body. Maintaining a healthy lifestyle, having regular exercise and consuming healthy, balanced diets are some of the effective ways to increase and activate PPARs in our body. On top of that, there is a more effective and convenient way to increase PPARs in our body: taking PPARs Supplement.


There are several brands offering PPARs Supplements in the market. Our Simply Nature PPARs has been around for many years with plenty of testimonials and reviews from medical doctors and users. It is highly popular in Singapore and The Philippines. Simply Nature PPARs is made with 100% natural plant-based whole food which are totally free from additives, binder, fillers and any artificial substances whereby it would work in synergy with chemotherapy, radiation therapy and even surgery. Hence, it is highly recommended for cancer patients.


There are 4 consumable forms for the Simply Nature PPARs which you could acquire: the tablet form, the extract powder, the liquid vials as well as a soft gel capsule.


1. The Simply Nature PPARs Extract Liquid


This is the most expensive Simply Nature PPARs products comparing to other Simply Nature PPARs Series products, but it is the most effective one as well. This is because each vial of liquid holds the amount of potency as high as 1,000 tablets. This PPARs Extract Liquid is meant for those with critical needs and anti-ageing purposes.

There are 6 liquid vials in a box of PPARs Extract Liquids.


2. The Simply Nature PPARs Plus Tablets


Comparing to other consumable forms, capsules and tablets are always the most convenient forms of supplements. The Simply Nature PPARs Plus Tablet contains almost 100 times more than normal vegetables of chlorophyll. Hence, it is beneficial for the blood purification and anti-toxic process of the body. It is beneficial for constipation issues.

The tablets are chewable and there are 150 tablets for each bottle of PPARs Plus Tablet.


3. The Simply Nature PPARs Extract Soft Gel Capsule


Comparing to tablets, soft gel capsules are more easily to swallow. From the perspective of taste, soft gel capsules have no taste or unpleasant odour.

30 capsules of soft gel PPARs concentrate extract in each pack of capsules.


4. The Simply Nature PPARs Extract Powder


Comparing to the other delivery forms of supplements like soft gel capsules and tablets, the extract powder is always easier and more effective for the body to absorb nutritional support. If you are facing the difficulty of swallowing capsules or tablets, this PPARs Extract Powder is your ultimate best choice.


The Simply Nature PPARs series is available online where you may get the products from Simply Nature’s official Lazada, Shopee account or the Simply Nature official website




To sum up, PPARs is indeed an effective supplement for patients suffering from breast cancer and other cancer. PPARs does not only combat and eliminate the mutated cells but also helps to alleviate side effects of cancer therapy, especially chemotherapy. Consumption of PPARs is not necessarily only for the sick, but is suitable for any healthy person too as an anti-cancer, immune system building supplement.


It will not be easy to deal with breast cancer, especially with the medications and therapy. However, it is important to manage the stress effectively as effective stress management always play a critical role in your health. Besides consuming PPARs supplement, it is also important to maintain a healthy lifestyle and a balanced diet. Talk to us if you are looking for an effective solution in treating breast cancer and we will refer our doctors to assess your current situation.

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