Updated: May 4, 2020
In this post, we will discuss about the supplements for diabetes with focus on PPARs supplement and how it actually helps people that are suffering from diabetes.
There are two types of diabetes, Type 1 and Type 2. Type 1 is due to inborn conditions while Type 2 diabetes is more due to diet and post birth conditions. Type 2 diabetes patients have been steadily increasing and affects more than 5% of the world population, with advanced countries such as USA, and even Singapore ranking at the top of the charts for Type 2 diabetes patients. In this post, we study the diabetic medical journals on PPARs and summarize the layman terms for your easy understanding.
Snapshot on PPARs Supplement for Diabetes:
1. Understanding Insulin Resistance and Progressive Deterioration of β-cell Functions
2. Loss Of Glucose-Sensing Ability
4. Improving Glucose Tolerance by Enhancing Insulin Sensitivity
5. Glucose Homeostasis Improved due to PPAR-γ agonists
6. Role Of PPAR-γ In The Glucose-Sensing Apparatus Of Pancreatic β-cells
7. Restoring β-cells of Type 2 Diabetes to a Normal State.
8. Role Of PPAR-γ In The Glucose-sensing Apparatus Of The Liver
9. PPAR-γ Agonists Positive Effects on Hepatic Glucose Metabolism By Lowering Free Fatty Acid Levels
10. PPAR-γ Found To Be Able To Directly Regulate The Genes Responsible For Glucose Homeostasis
11. PPAR-γ Participation Helped Improve Glucose Homeostasis In Type 2 Diabetic Patients
12. PPARs Supplement
13. Where to buy high-quality PPARs Supplement?
Understanding Insulin Resistance and Progressive Deterioration of β-cell Functions
The major underlying causes of type 2 diabetes are insulin resistance and progressive deterioration of β-cell functions according to this research from Yonsei College of Medicine. There are many causes including aging, genetic defects, environmental factors, and obesity that triggers the development of insulin resistance. The moment insulin resistance develops in several tissues, insulin-stimulated glucose disposal is decreased and adipocytes release many free fatty acids. Furthermore, increased free fatty acids inhibit the insulin action on liver, resulting in increased gluconeogenesis in the hyperglycemic state. Hence, secretory demand of insulin from β-cells is increased.
Loss Of Glucose-Sensing Ability
So long as the pancreatic β-cells can sense blood glucose levels and secrete sufficient insulin to compensate for insulin resistance, diabetes does not happen. Hence, type 2 diabetes only develops in the context when both one’s insulin resistance and β-cell functions fail. The loss of glucose-stimulated insulin secretion (GSIS) happening as a result from the loss of glucose-sensing ability, confirms the failure of the β-cell.
Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear hormone receptor that comprises an agonist-dependent activation domain (AF-2), DNA binding domain, and agonist-independent activation domain (AF-1). Upon the binding of the agonists, PPAR-γ heterodimerizes with retinoid X receptor-α and activates the transcription of target genes through the binding of the PPAR response element (PPRE).
Improving Glucose Tolerance by Enhancing Insulin Sensitivity
Synthetic agonists of PPAR-γ, thiazolidinediones (TZDs), have been developed to improve glucose tolerance by enhancing insulin sensitivity and restoring the function of β-cells in diabetic patients. Improved glucose homeostasis may be achieved either by systemic insulin sensitization or by direct action of PPAR-γ on the transcription of genes involved in the glucose disposal. There has been clinical proof supporting the direct action of PPAR-γ on glucose metabolism. PPAR-γ is also known to increase the glucose-sensing ability of pancreatic β-cells.
Glucose Homeostasis Improved due to PPAR-γ agonists
In the backdrop of this study, the researchers were able to present evidence that PPAR-γ agonists directly activate genes of the glucose-sensing apparatus in liver and pancreatic β-cells. The data showed a direct involvement of liver and pancreatic β-cells in the improvement of glucose homeostasis in type 2 diabetes patients using PPAR-γ agonists.
Role Of PPAR-γ In The Glucose-Sensing Apparatus Of Pancreatic β-cells
Evidence has shown that PPAR-γ agonists can protect the β-cells from apoptosis and restore the function of β-cells, including GSIS. The activation of PPAR-γ leads to restoration of the glucose-sensing ability of β-cells through the activation of GLUT2 and βGK gene expression in diabetic patients.
Restoring β-cells of Type 2 Diabetes to a Normal State
In a study involving diabetic rats, researchers have arrived at the following findings: restoration of GSIS and a decrease in basal insulin secretion are achieved by TZD treatment in the primary isolated islets from diabetic ZDF rats. These TZD-induced changes of GSIS in isolated diabetic β-cells resemble the hyperinsulinemic pattern of compensated β-cells. From this study and contextual understanding, it is assumed that TZDs play some role in restoring β-cells of type 2 diabetes to a normal state.
Role Of PPAR-γ In The Glucose-sensing Apparatus Of The Liver
Other than measuring effects on pancreatic β-cells, researchers also attempted to find out the effects of PPARs on the liver, similarly using rats in the study. TZDs are known to be able to reduce free fatty acid and hepatic glucose production. When diabetic ZDF rats are treated with PPAR-γ agonists, PEPCK and glucose-6-phosphatase expressions are reduced and GK and lipogenic gene expressions increased, this suggests that PPAR-γ agonists reduce gluconeogenesis and increase adipogenesis and glycolysis. But in the study, one thing that is still unclear is if these effects are due to a direct action of PPAR-γ on the liver or secondary effects of increased systemic insulin sensitivity.
PPAR-γ Agonists Positive Effects on Hepatic Glucose Metabolism By Lowering Free Fatty Acid Levels
PPAR-γ agonists reduce circulating triglyceride and free fatty acid levels by repartitioning fatty acids in adipocytes. Increased free fatty acids are associated with hepatic insulin resistance, resulting in the increased gluconeogenesis. In diabetic ZDF rats treated with PPAR-γ agonists, a PPAR-γ-induced decrease of free fatty acid levels precedes the decrease of glucose and triglyceride levels, suggesting that a decrease in free fatty acid levels may be important for the insulin-sensitizing action of PPAR-γ agonists. Hence, PPAR-γ agonists may indirectly affect hepatic glucose metabolism by lowering free fatty acid levels.
PPAR-γ Found To Be Able To Directly Regulate The Genes Responsible For Glucose Homeostasis
The fact that liver expresses moderate amounts of PPAR-γ led researchers to explore the possibility that PPAR-γ can directly regulate the genes responsible for glucose homeostasis. Indeed, there is presence of PPRE in the glucose-sensing apparatus of the liver. Researchers identified functional PPREs in the promoters of GLUT2 and GK in pancreatic β-cells and liver. This work suggests that the antidiabetic action of TZDs could be not only due to systemic improvement of insulin sensitivity but also due to direct action of PPAR-γ on the genes involved in the glucose transport and subsequent glycolysis. Therefore, based on the direct action of PPAR-γ on the glucose-sensing apparatus in liver and β-cells of pancreas, the antidiabetic action of TZDs can be summarized as combinatorial effects involving several target tissues.
Image taken from TMEDWEB
PPAR-γ Participation Helped Improve Glucose Homeostasis In Type 2 Diabetic Patients
Prior findings has found that increased expression of GK and GLUT2 in the liver can increase glycolysis and glycogen synthesis. Hence, TZDs may decrease blood glucose and insulin levels efficiently. Taken together, PPAR-γ-mediated activation of GLUT2 and GK in liver and β-cells is found to be likely to contribute to the beneficial effects by which TZDs improve glucose homeostasis in type 2 diabetic patients. The research work was supported by a grant [R13-2002-054-01001-0 (2002) to Y.A.] from the Basic Research Program of the Korea Science and Engineering Foundation.
In short, PPARs is able to enhance the sensitivity of insulin and regulate the glucose level in the blood. In another way, PPARs play a significant role in enhancing the sensitivity of insulin and insulin secretion thereby reducing the glucose level in the blood. This will thus be the diabetes treatment which helps the diabetic patient to much better control the glucose level.
Furthermore, PPARs also has properties in:
ii. Reducing obesity and heart diseases
v. Enhancing one’s Immune System
Where to buy high-quality PPARs Supplement?
With the main objectives of meeting every consumers’ preferences and to ensure that the PPARs is easily released and absorbed by the body, Simply Nature offers PPARs in four different consumable forms: the tablet form, the extract powder, the liquid vials as well as soft gel capsule.
1. The Simply Nature PPARs Extract Liquid
This is the most expensive Simply Nature PPARs products comparing to other consumable forms but the most effective one as well. This is because each vial of liquid holds the amount of potency as high as 1,000 tablets. This is meant for those with critical needs and anti-ageing purposes.
2. The Simply Nature PPARs Plus Tablets
Comparing to other consumable forms, capsules and tablets are always the most convenient forms of supplements. The Simply Nature PPARs Plus Tablet contains almost 100 times more than normal vegetables of chlorophyll. Hence, it is beneficial for the blood purification and anti-toxic process of the body. It is beneficial for constipation issues.
3. The Simply Nature PPARs Extract Soft Gel Capsule
Comparing to tablets, soft gel capsules are more easily to swallow. From the perspective of taste, soft gel capsules have no taste or unpleasant odour.
4. The Simply Nature PPARs Extract Powder
Comparing to the other delivery forms of supplements like soft gel capsules and tablets, the powder is always easier and more effective for the body to absorb nutritional support.
If you are facing the difficulty of swallowing capsules or tablets, this PPARs Extract Powder is your ultimate best choice.
The Simply Nature PPARs product series are not only sold through medical doctors, it is also available on the official Simply Nature Shopee and Lazada websites or the Simply Nature official website @ www.simplynature.asia.
Conclusion: PPARs supplement for Diabetes
If you or your loved ones are suffering from diabetes, or if you are diagnosed to be pre-diabetic, fret not, PPARs supplement can be a great help to you. By consuming it on a regular basis as a supplement, you will be able to control the glucose level in your blood and as much as possible resume normal daily activities. Here is a video testimonial from one of our clients Mary Josephine on how PPARs supplement helped in her diabetes journey:
If you have been diabetic for a number of years, do get in touch with us as soon as you can. We will assign you a doctor to diagnose your current health condition and he or she shall recommend possible remedies including the type of dosage of PPARs supplement suitable. Find out more about treating diabetes using PPARs supplements from Simply Nature here.