What are early Lupus symptoms and how to treat using PPARs?

What are early Lupus symptoms and how to treat using PPARs?

According to the Lupus Foundation of America, there are at least 5 million people worldwide, suffering from Lupus. Lupus is a devastating and life-changing disease that currently has no cure. Women are more likely to get infected with lupus. Ninety percent (90%) of lupus patients are women. Most people with lupus develop the disease between the ages of 15-44. In this post we will be also highlighting some early lupus symptoms so you will be able to be on your guard as well as treating lupus using PPARs.


Overview of “What are early lupus symptoms and how to treat using PPARs”:

1. What is Lupus?

2. Is Lupus Fatal?

3. What are the early symptoms of Lupus?

4. What is PPARs?

5. How to treat Lupus Symptoms with PPARs?

6. Where and How can you Buy PPARs?


What is Lupus?


Lupus is a long-term autoimmune disease in which the body’s immune system becomes hyperactive and attacks normal, healthy tissue. Lupus is a chronic autoimmune disease that can damage any part of the body, from the skin, to the joints, to the organs.

Selena Gomez is one of the celebrities who has been suffering from Lupus.


9 Celebrities with Lupus


Lupus has “brought” her serious complications, many organs are affected, and kidneys are the most affected organs. She had to go through a kidney transplant to survive.


Interview with Selena Gomez regarding Lupus


There are 4 different forms of Lupus with different complications.


1. Systemic lupus erythematosus (SLE)

- SLE is the most common type of lupus which accounted for approximately 70% of all lupus cases. Severeness of SLE can be mild or vital. This is because SLE may cause severe damage towards the major organs like the heart, lungs, kidneys and brain.


2. Cutaneous lupus erythematosus (CLE)

- CLE is limited to the skin which the immune system only attacks the skin. The complications are severely irritating which might cause various types of rashes and lesions. Around 10% of lupus cases in the world are CLE.


3. Drug-induced lupus

- Drug-induced lupus is caused by certain prescription of medications (drugs). Around 10% of lupus cases in the world are drug-induced lupus. This type of lupus is normally caused by high doses of certain medications. Symptoms of drug-induced lupus are similar to SLE. However, the symptoms are usually subsided when the medications are discontinued.


4. Neonatal Lupus

- Neonatal lupus is a very rare condition where it affects infants of “lupus mom”. This type of lupus is caused by antibodies from the mother acting upon the fetus in the womb. At the initial stage after birth, the baby may experience the symptoms like skin rash, liver problems and low blood cell counts. Fortunately, these symptoms typically disappear completely after 6 months and it does not last any long-term damage or effect towards the baby.


Is Lupus Fatal?


Seriousness of lupus can range from mild to life-threatening.


Lupus is caused by the “malfunction” of the immune system in which our immune system attacks the healthy cells and tissues. Lupus can damage many parts of the body, including the joints, skin, kidneys, heart, lungs, blood vessels and brain.


Lupus itself is not as fatal, but the long-term complications of lupus are life-threatening. Kidney failure, cardiovascular disease and infections are the most common complications of lupus mortality.


What are the early symptoms of Lupus?


Lupus is a “tricky” disease in which the early symptoms of lupus might be difficult to detect as it might “mimic” symptoms of other illnesses, making it challenging to diagnose. These signs and symptoms included fatigue, fever, achy joints and headaches. These symptoms are often overlooked as harbingers of a different disease like flu.


However, lupus has a distinctive sign in which lupus patients might experience facial rash (butterfly rashes) across nose and both cheeks. Nearly 2/3 lupus patients will experience butterfly rashes, and the symptom normally worsen by exposure to the sun.


Besides, photosensitive rash is another common early symptom of lupus. This means that the skin is sensitive to sun exposure and would trigger rashes to develop, particularly on the face and upper arms.


Other common early symptoms of Lupus included:


i. Hair Loss

ii. Pain in chest with deep breathing

iii. Oral Ulcers

iv. Sudden weight fluctuations (weight loss or weight gain)

v. Arthritis

vi. Lung problems

vii. Heart problems

viii. Kidney problems

ix. Psychosis

x. Blood cell and immunological abnormalities


These symptoms may develop slowly or appear suddenly. The symptoms might be mild or serious, and it might be chronic or come and go. Sometimes, there may be no visible symptoms shown too. Lupus manifests differently in every person with the disease.


What is PPARs?



The Peroxisome proliferator-activated receptor (PPARs) is a group of nuclear receptor proteins that are beneficial in increasing and regulating the expression of genes. PPARs is an emerging “star” in the biomedical industry which has been known as the one most promising biomedical molecule.


The PPARs act on DNA response elements with the nuclear retinoic acid receptor. PPARs are involved in various independent and DNA-dependent molecular and enzymatic pathways in adipose tissue, liver, and skeletal muscles.


PPARs are beneficial and crucial for the body in fighting diseases and providing fuels and energy to the cells.


With clinical tests and medical proofs, PPARs are having numerous benefits for the body, which included:


i. Enhances Blood Sugar Regulation for Diabetic


PPARs increase Fibroblast Growth Factor 21(FGF-21) which is a hormone that regulates important metabolic pathways. It is beneficial to enhance insulin sensitivity and glucose in the blood. Shortly, PPARs act as a key to facilitate the sensitivity of insulin and insulin secretion thereby reducing the glucose in the blood. This will be able to reduce the chance of getting diabetes and act as a controller for a diabetic patients.


ii. Anti-Inflammation


PPARs also play the roles of anti-inflammation and block inflammation. The PPARs are beneficial to reduce pain and inflammation and further prevent the production of various pro-inflammatory and angiogenic enzymes. Besides, PPARs have also been recognized for contributing significantly in the immune response through its ability to avoid the expression of inflammatory cytokines and directing various immune cells toward anti-inflammatory phenotypes.


iii. Reduce obesity and heart diseases


Activation of PPARs increases metabolism and body function which is crucial to treat diabetes mellitus, obesity, hypercholesterolemia and hypertension. PPARs will activate fatty acid catabolism and take part in controlling the assembly of lipoprotein. The excretion of PPARs which causes the browning of white fat which will be able to facilitate in the fight against obesity.


Therefore, PPARs are beneficial in lowering blood triglyceride, hence lowering the density of Lipoprotein Cholesterol. PPARs have also been shown to have the function to reduce blood pressure and decrease heart disease.


iv. Anti-Cancer Effect


PPARs Treatment & Prevention Of Diseases


According to studies, when used correctly, PPARs will be very favourable to cancer therapy.

PPARs stimulation appears to inhibit proliferation of human colon cancer cell lines and to reduce poly formation. PPARs increase the antineoplastic effects of malignant cells. In other words, PPARs inhibit growth of proliferation and cancer cells (the bad proliferation).


v. Anti-aging


Free radicals are causal agents in the process of aging. PPARs support the healing process of damaged body tissues and are beneficial in rejuvenation of cells. Besides, the antiapoptotic characteristic of PPARs has made it an effective “agent” in anti-aging.


There are three subtypes of PPARs: the PPAR alpha, the PPAR beta/delta and the PPAR gamma.


The PPAR Alpha is widely expressed in body tissues with high fatty acid catabolic activity like the liver, heart and intestine. Activation of the PPAR alpha is beneficial in lowering triglyceride level and is involved in regulation of energy homeostasis.


The PPAR beta/delta presents in many tissues but markedly in the brain, lungs, skeletal muscle and skin. It promotes the oxidation of fatty acids, ketone body synthesis and glucose sparing.


The PPAR gamma is ubiquitous. It presents in almost all tissues including heart, muscle, colon, kidney, pancreas and spleen. PPAR gamma promotes the triglyceride storage which is highly favourable for the regulation of lipid and glucose metabolism.


How to Treat Lupus Symptoms with PPARs?


In fact, there is no 100% cure for lupus. Treatments and medications given by doctors are to alleviate and control lupus symptoms as well the complications caused by lupus.


According to studies, PPARs are helpful for reversing the symptoms of lupus by reducing the hypertension, endothelial dysfunction and organ damages caused by lupus. Besides, PPARs also are effective in inhibiting inflammatory mediators.


The PPAR gamma plays the most crucial role in relieving the lupus symptoms and complications. PPAR gamma which is rich with anti-atherogenic and anti-inflammatory properties is involved in the regulation of inflammation and immunity. PPAR gamma regulates the inflammatory signal initiated by activation of CD40. PPAR gamma also is crucial in reducing pain and prevention of the production of various pro-inflammatory and angiogenic enzymes.


In terms of immunity, PPAR gamma and its ligands are indeed the most critical one for the modulation of immune cells like monocytes, T cells and NK cells and inflammatory reactions.


Besides, as per mentioned earlier, one of the powerful functions of PPARs is that it rejuvenates cells and supports the healing process of damaged body tissues. As we know, lupus “tricks” the immune system to attack our body cells and tissues. Hence, in this condition, PPARs are critical to alleviate and even reverse the complications of lupus by repairing the organs that were affected by lupus.


Refer below as the testimony from Kat Catapusan who has been taking PPARs Supplement during her lupus healing journey.


Kat Catapusan on Lupus healing with SimplyNature PPARS



Where and how can you buy PPARs Supplements?



There are several simple and effective ways to increase and activate PPARs in our body. Maintaining a healthy lifestyle which includes regular exercises and balanced diets are one of the effective manners to increase and activate PPARs in our body.


Despite this, there is a more effective and convenient way to increase PPARs in our body to alleviate the lupus symptoms: taking the PPARs Supplement. PPARs Supplement works like the way we take Vitamins or supplements to boost certain nutrients that we are lacking off or to boost certain body tissues.


With the increasing demand of PPARs Supplement, there are numerous brands offering PPARs supplements in the market and it is crucial to choose and select the supplement wisely and carefully.


There are several brands offering PPARs Supplements in the market. Our Simply Nature PPARs Series is highly popular among users in Singapore and The Philippines. If you are in Singapore or The Philippines, you can easily reach out to Simply Nature’s PPARs. Besides, there are plenty of testimonials and reviews from medical doctors and users, proving the effectiveness of Simply Nature PPARs.


The Simply Nature PPARs is available in 4 different consumable forms: the tablet form, the extract powder, the liquid vials as well as a soft gel capsule.


1. The Simply Nature PPARs Extract Liquid


The Simply Nature PPARs Extract Liquid is the most expensive Simply Nature PPARs product compared to other Simply Nature PPARs Series products, but it is the most effective one as well. This is because each vial of liquid holds the amount of potency as high as 1,000 tablets. This PPARs Extract Liquid is meant for those with critical needs and anti-ageing purposes.


2. The Simply Nature PPARs Plus Tablets


Compared to other consumable forms, capsules and tablets are always the most convenient forms of supplements. The Simply Nature PPARs Plus Tablet contains almost 100 times more than normal vegetables of chlorophyll. Hence, it is beneficial for the blood purification and anti-toxic process of the body. It is beneficial for constipation issues.


3. The Simply Nature PPARs Extract Soft Gel Capsule


Compared to tablets, soft gel capsules are easier to swallow. From the perspective of taste, soft gel capsules have no taste or unpleasant odour. The Simply Nature PPARs Extract Soft Gel Capsule contains 30 capsules per package.


4. The Simply Nature PPARs Extract Powder


Compared to the other delivery forms of supplements like soft gel capsules and tablets, the powder is always easier and more effective for the body to absorb nutritional support.If you are facing the difficulty of swallowing capsules or tablets, the Simply Nature PPARs Extract Powder is your ultimate best choice.


The Simply Nature PPARs series is available online too which you may get the products from Simply Nature’s official Lazada, Shopee account or from our Simply Nature official website @simplynature.asia.




It is not easy to deal with lupus especially with the pains and complications which will affect our daily lives. However, it is crucial to manage the stress effectively. Effective stress management always plays a critical role in your health. Hence, it is important to maintain a healthy lifestyle, balanced diet and manage stress effectively.


Based on studies and patients of ours taking PPARs, the supplement has proven effective for alleviation of lupus symptoms and complications. This is mainly due to its anti-inflammatory and body tissue healing properties. It is crucial in relieving the pain and inhibiting inflammation caused by lupus while helping the organs to heal faster from damages caused by the immune system.


Our Simply Nature PPARs is made up of 100% natural plant-based whole food which are totally free from additives, binder, fillers and any artificial substances. There are no side effects. If you have been struggling with lupus and would like to know how Simply Nature’s PPARs have been effective, do reach out to us either via our contact form on our website or our Facebook messenger.


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