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How does PPAR help in Weight Loss?

Updated: May 4

If you have ever tried to lose weight, then you will know how challenging it can be. You have to be 101% determined and dedication to shed off the extra pounds. Despite diets and exercises, you may have tried some weight loss supplements to burn the extra calories yet still are unable to do so in achieving your ideal weight.


Positive findings: research has found that the Peroxisome proliferator-activated receptors (PPARs) is a potentially effective fat-burning “catalyst” for almost all body types.

Snapshot of PPARs helping out in Weight Loss:

1. What is PPARs?

2. HOW does PPARs help in weight loss?

3. PPARs vs Weight Loss Pills

4. How to Increase or Activate PPARs in your Body?

5. Where & How can I buy PPAR Supplements?

6. Conclusion

What is PPARs?

The Peroxisome proliferator-activated receptors (PPARs) is a group of nuclear receptor proteins that attach to the DNA to increase and regulate the expression of genes. There are three subtypes of PPAR: the PPAR alpha, the PPAR beta/delta and the PPAR gamma.

The PPAR alpha presents in the skeletal muscle, the liver and the heart which plays the crucial role to lower the triglyceride level and energy homeostasis. The PPAR beta/delta is active in many tissues and plays an important role to regulate the oxidation of fatty acids, ketone body synthesis and glucose sparing. While the PPAR gamma, which is the ubiquitous and the most “popular” PPAR subtype is important in the regulation of lipid and glucose metabolism. This is crucial in allowing our body to adapt to the prevailing nutritional environment.

How does PPARs help in weight loss?


There are numerous scientific researches and medical evidence, studying the effectiveness of PPARs in combating excessive calories. According to research studies, PPARs is playing an essential role in boosting the body’s metabolism rate. Basically, PPARs increases FGF-21 in our body. FGF-21 is beneficial in lowering body weight in obese by increasing the body’s energy expenditure, fat utilization and excretion.


Despite increasing the body’s energy expenditure, PPAR also triggers the browning of White Fats (BAT), which has been a key focus area in weight loss research. BAT is well-known for its fat-burning potential. A substantial amount of energy is needed during the process of BAT, resulting in the energy dissipation of BAT to divert excess fat into heat production.


Among the three subtypes of PPARs, PPAR gamma plays a protective role when facing abundant foods. PPAR gamma provides us more leeway to eat more and having that to go into fat storage instead of stressing our body and causing inflammation. It is helpful in increasing energy expenditure and hence burning more calories.


More than 50% of metabolism occurs in skeletal muscles. Thus, activities involved in muscle contraction, particularly exercises may significantly increase our energy expenditure. PPAR delta is the most abundant PPAR subtype presents in the skeletal muscles. It is an important regulator of skeletal muscle metabolism to breakdown fats or glucose into energy to fuel the muscle contraction. In short, PPAR delta regulates skeletal muscle to burn stored fat into energy which is beneficial for weight loss.


PPAR alpha is the most beneficial type of PPAR in lowering our body weight. This is because one of the main features of PPAR alpha is that it promotes fat burning in the liver and releases the stored energy (our excessive fats).

PPARs vs Weight Loss Pills

When it comes to weight loss, many of us would have come across pills touting claims to bringing weight loss. This is how weight loss pills work:


1. Increase your body’s baseline metabolic rate (energy expenditure)


This type of weight loss pills/ drugs normally known as fat burners or thermogenesis. It works by boosting the metabolism in our body and hence increase the fat burning.

Some of the most popular thermogenic supplements include caffeine, green tea, capsaicin and other plant extracts.


Fat burners are designed to increase the activity of several hormones: adrenaline noradrenaline and dopamine which stimulate the fat cells to release fatty acids into our bloodstream and hence converted into energy. Despite boosting fat metabolism, some ingredients of fat burners like caffeine and capsaicin reduces our appetites as well.

Here are some side effect(s):

i. Some people tend to start experiencing restlessness, anxiety, or jitters after consuming fat burners for sometimes.

ii. It might raise blood pressure, which could be hazardous in the long term. Not recommended to users with high blood pressure.

iii. The mixture of ingredients might be damageable to the liver. Without proper precautions, extended use might lead to a risk of liver damage or even failure.

2. Fill you Up/ Suppress your appetite

This type of pills will make you feel full always. As a result, you consume less food and loss of weight.

One common drug pill types is Lorcaserin. It acts on serotonin receptors in the brain to promote feelings of fullness, thus encouraging users to eat less. In other words, it “tricks” the brain to send out the signal that we are not hungry so we eat less.

Here are some side effect(s):

i. This type of pills is not recommended for pregnant women.

ii. Might cause side effects such as drowsiness, headache and constipation.

3. Block/ Slow Down Fats Absorption


This type of weight loss pills work by inhibiting the body from the extraction of fats from the food we ate. For instance, like Orlistat. It reduces the activation of lipases which produced by the pancreas and gastrointestinal tract. Lipases extract fat from the our food intake and absord them into the blood which will then be converted into energy or be stored by the body. Hence, by inhibiting the lipase function, Orlistat prevents the fats from being absorped into our body. Instead, they are excreted through feces.

Here are some side effect(s):

i. It does not completely block or prevent all fat uptake; it only stops around 30-40 per cent of fats from being absorbed. So, the body will still store extra fats if you do not control your diet.

ii. It might cause gastrointestinal distress and there might be an imposed risk of liver malfunction if not taken carefully.

PPARs is different from weight loss pills and fat burners, and it can be highly beneficial in other perspectives because despite encouraging the metabolism for weight loss, PPARs in fact decreases triglyceride and LDL-cholesterol (the bad cholesterol) levels while increasing insulin sensitivity and HDL-cholesterol (the good cholesterol) levels. So, you get to lose weight while being healthier.

How to Increase or Activate PPARs in your Body?

There are several simple and effective manners to increase PPARs in our body:


1. Exercise



Exercise is associated with energy expenditure and PPARs works by increasing the energy consumption. PPAR delta is related to energy production. Hence, by doing more exercise, the skeletal muscle will naturally produce more PPAR delta to produce more energy for consumption. Endurance exercise (aerobic) like jogging, running, dancing and biking are beneficial to increase PPAR delta in skeletal muscle.

2. Ketosis



Ketosis is a natural metabolic state. It involves the body producing ketone bodies out of fat and using them for energy instead of carbs. You can get into ketosis by following a very low-carb, high-fat ketogenic diet. Ketogenic transcriptional program is a crucial enzymatic machinery of ketosis and PPAR is the chief transcription factor responsible for proper ketogenic transcriptional program.

3. EPA + DHA (Fish Oil)



Consuming fish oil (EPA + DHA) that are highly polyunsaturated and readily undergo oxidation. According to studies, oxidized fish oil potently activated PPAR alpha.

4. Plant Oils


Consuming plant oils, especially thyme oil is an effective activator PPAR alpha and gamma.

5. PPARs Supplements


If you think you would like to have a faster or more convenient way to increase and activate PPARs in your body, you might want to consider taking PPARs Supplements which are effective in boosting PPARs.

Where & How can I buy PPAR Supplements?

The Simply Nature PPARs is one of the highly recognized PPARs Supplements. It has offices both in Singapore and The Philippines. You can also check out their reviews from even doctors and patients.

There are 4 consumable forms for the Simply Nature PPARs which you could get: the tablet form, the extract powder, the liquid vials as well as a soft gel capsule.

1. The Simply Nature PPARs Extract Liquid


This is the most expensive Simply Nature PPARs products comparing to other consumable forms but the most effective one as well. This is because each vial of liquid holds the amount of potency as high as 1,000 tablets. This is meant for those with critical needs and anti-ageing purposes.

2. The Simply Nature PPARs Plus Tablets


Comparing to other consumable forms, capsules and tablets are always the most convenient forms of supplements. The Simply Nature PPARs Plus Tablet contains almost 100 times more than normal vegetables of chlorophyll. Hence, it is beneficial for the blood purification and anti-toxic process of the body. It is beneficial for constipation issues.

3. The Simply Nature PPARs Extract Soft Gel Capsule



Comparing to tablets, soft gel capsules are more easily to swallow. From the perspective of taste, soft gel capsules have no taste or unpleasant odour.

4. The Simply Nature PPARs Extract Powder



Comparing to the other delivery forms of supplements like soft gel capsules and tablets, the powder is always easier and more effective for the body to absorb nutritional support.

If you are facing the difficulty of swallowing capsules or tablets, this PPARs Extract Powder is your ultimate best choice.

The Simply Nature PPARs series is not only sold through medical doctors. As a supplement, the products are available online too. You may get the products from Lazada, Shopee or the Simply Nature official website @ www.simplynature.asia.

Conclusion on PPARs helping your weight loss


In conclusion, if you have been trying weight loss pills, it might not be in your health interest to undergo the side effects that might wreak more havoc to your body. More importantly, as these drug pills might not subject to regulated manufacturing standards and high quality clinical testing, it is almost impossible to know how they will work in the body and, consequently, there might be some unforeseen health problems. Never risk your health in that way.


Perhaps it is time to give your body a chance to try some healthy diets or supplements to boost the PPARs in your body instead. It is considered a natural and effective way to boost your energy consumption and lose weight, at the same time, staying healthy. Remember, staying safe always comes first! Talk to us on Facebook if you have more questions about how PPARs can help you in your weight loss journey!

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