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How does PPARs supplement for Hemorrhoids work



Nearly three out of four adults will have haemorrhoids from time to time. Symptoms of haemorrhoids are not serious but there are possibilities that it might lead to complications like strangulated haemorrhoids and blood clot which can lead to extreme pain. Although the symptoms are not fatal but it might be very inconvenient and sometimes embarrassing - itchiness around the anal region, especially when one is in public.


There are numerous ways to treat haemorrhoids with home remedies and PPARs is one of the effective supplements which relieve and even treat haemorrhoids.


Thus, in today’s post, we are going to explore how PPARs supplement work to treat haemorrhoids.


Snapshot of how does PPARs supplement for haemorrhoids work:


1. Haemorrhoids and Symptoms

2. Causes of Haemorrhoids

3. Diets to Treat Haemorrhoids

4. PPAR Supplement for Haemorrhoids

5. Simply Nature PPARs – The 100% Natural PPAR Supplement


Haemorrhoids and Symptoms


Haemorrhoids (HEM-uh-roids), also called piles, are swollen veins in your anus and lower rectum, similar to varicose veins. Haemorrhoids can develop inside the rectum (internal haemorrhoids) or under the skin around the anus (external haemorrhoids).


The veins around the anus tend to stretch under pressure and may bulge or swell.


There are two main types of haemorrhoids: the internal haemorrhoids and the external haemorrhoids. Internal haemorrhoids are far enough inside the rectum which is covered with a lining known as mucosa that is less sensitive to stretch, temperature and pain. Hence, people with internal haemorrhoids are less likely to feel pain. The external haemorrhoids are under the skin around the anus, surrounded by more pain-sensing nerves. Thus, people with external haemorrhoids are more sensitive towards pain.


Symptoms of haemorrhoids includes:


1. Itching or irritation around the anal region

2. Pain or discomfort around the anal region

3. Swelling around the anal region

4. Bleeding, normally such as blood in the stool

5. Internal haemorrhoids normally comply with painless bleeding during bowel movements

6. Tissues that bulge around the anal region may result in pain and irritation when a haemorrhoid has been pushed through the anal opening.

7. There might be lumps near or around the anal region

8. Inflammation might happen too especially when there is wound due to the hard push

9. Severe pain when there is blood clot or strangulated haemorrhoid

Coughing, sneezing, and vomiting could worsen the symptoms of haemorrhoids too.


Causes of Haemorrhoids


Haemorrhoids are developed due to the increased pressure in the lower rectum. There are numerous possible causes of increasing pressure in the lower rectum.


1. Sitting for long periods of time on the toilet

Haemorrhoids may happen if you sit on the toilet too long because when you sit on the toilet, your anus relaxes, allowing the veins around to fill with blood, which then puts pressure on those veins.


2. Having chronic diarrhoea or constipation


When a person is having chronic diarrhoea, it will impact the overall health, not only influencing the body tissues of rectum.

People tend to strain on the bowel movement, putting pressure towards the rectum and anal when they are having constipation. Regular straining and pressures on the body tissues due to chronic constipation cause the veins around the rectum and anal region to swell, resulting in haemorrhoids.


3. Obesity


Haemorrhoids are commonly experienced among individuals with obesity. This is because they have excess weight, or pressure constricting the veins and blood vessels surrounding the anal and colon.


4. Pregnancy and Vaginal Delivery


This can also happen when a person is pregnant, because the baby's weight puts pressure on the lower rectum and anal region, stressing the veins and hence resulting in haemorrhoids.


Vaginal delivery will apply pressure to the blood vessels in the rectum too.


5. Having a low-fibre diet


Having low-fibre diet will lead to constipation which applies the same pressure towards the rectum tissues as chronic constipation.


6. Regular heavy lifting


Weightlifting needs the athletes to hold breathe while lifting the weight and exhale. In this condition, the air in the lungs will turn downward, putting pressures on the internal organs and blood vessels in the rectum, causing the veins to swell and hence, haemorrhoids.


This is the same when a person’s work requires him or her to lift heavy objects regularly.


7. Having anal intercourse


As one ages, the risk of haemorrhoids increases. This is because the body tissues that support the veins in the rectum and anal region can weaken and stretch. People who stand or sit for long stretches of time are at greater risk, too.


Diets to Treat Haemorrhoids


Fortunately, effective options are available to treat haemorrhoids. Many people get relief with home treatments and lifestyle changes. Taking PPARs Supplement is one of the helpful remedies to treat haemorrhoids. PPARs is rich in the anti-inflammation and blocking inflammation properties. PPAR gamma which is rich with anti-atherogenic and anti-inflammatory properties is often involved in the regulation of inflammation. PPARs will modulate the body’s ability to regulate and decrease inflammation.


PPARs can help to reduce pain and inflammation and further prevent the production of various pro-inflammatory and angiogenic enzymes.



This is beneficial to relieve the swell in the veins around the rectum and anal region, improving the haemorrhoids.


Activation of PPARs will enhance immunity cell proliferator capability which in other words, PPARs will boost our immune system. PPARs is effective to induce an immune profile similar to dominance of Th2 Cells. In terms of immunity, PPAR gamma and its ligands are indeed the most critical one for the modulation of immune cells like monocytes, T cells and NK cells and inflammatory reactions.

Besides, PPARs has also been recognized in contributing significantly in the immune response through its ability to avoid the expression of inflammatory cytokines and directing various immune cells toward anti-inflammatory phenotypes making PPARs to be effective in inhibiting inflammatory mediators. This is helpful to prevent bacteria from growing around the anal region and hence reduce the irritation and itchiness due to haemorrhoids.


PPARs plays a major regulatory role in energy homeostasis and metabolic function. This means that PPARs will direct the exact amount of nutrients needed by your body to the exact tissues or organs, unifying the biological system, functions and processes. Chronic constipation and diarrhoea can occur due to a lack of nutrients, other than factors such as infections or functional disorder of body tissues. PPARs is able to influence the body to direct the exact amount of nutrients to the exact body tissues to become effective in improving chronic constipation and diarrhoea. When these chronic issues are improved, less pressure is applied to the veins in the rectum and hence, improving the condition of haemorrhoids.


Furthermore, activation of PPARs increases metabolism and body function which is crucial to treat diabetes mellitus, obesity, hypercholesterolemia and hypertension. Obesity is one of the common causes of haemorrhoids.

PPARs Supplement for Haemorrhoids



The Peroxisome proliferator-activated receptors (PPARs) is a group of nuclear receptor proteins that attach to the DNA to increase and regulate the expression of genes. PPARs is beneficial in increasing and regulating the expression of genes. PPARs is beneficial and crucial for the body in fighting diseases and providing fuels and energy to the cells.

PPARs plays the role as a transcription factor that regulates the expression of genes, including the regulation of cellular differentiation, development and metabolism of body tissues.


PPARs also acts on DNA response elements with the nuclear retinoic acid receptor. PPARs are involved in various independent and DNA-dependent molecular and enzymatic pathways in adipose tissue, liver, and skeletal muscles.


PPAR is divided into three subtypes or isoforms: the PPAR alpha, the PPAR gamma, and the PPAR beta/ delta.


The PPAR Alpha is widely expressed in body tissues, including the skeletal muscle, the liver and the heart which plays the crucial role to lower the triglyceride level and energy homeostasis. The PPAR beta/delta is active in many tissues and plays an important role to regulate the oxidation of fatty acids, ketone body synthesis and glucose sparing. PPAR beta/ delta also is effective in inhibiting inflammatory mediators. While PPAR gamma, which is ubiquitous and the most ‘popular’ PPAR subtype, play an important role in the regulation of lipid and glucose metabolism.


PPARs has been known to be one of the most promising biomedical molecules in the biomedical industry due to its ‘ultimate’ benefits towards the body. This includes improving chronic diseases like obesity, diabetes, kidney problems, and even cancer.